See the Lecture Summary

No Readings

Epidemiology of Sperm Counts

See the Lecture Summary

Carlsen, E., A. Giwercman, et al. "Evidence for Decreasing Quality of Semen During Past 50 Years." British Medical Journal 305, no. 6854 (1992): 609–13.

Saidi, J. A., D. T. Chang, et al. "Declining Sperm Counts in the United States? A Critical Review." The Journal of Urology 161, no. 2 (1999): 460–62.


Spermatogenic Cycle

See the Lecture Summary

Van Pelt, A. M., and D. G. De Rooij. "Synchronization of the Seminiferous Epithelium After Vitamin A Replacement in Vitamin A-deficient Mice." Biology of Reproduction 43, no. 3 (1990): 363–7.

Franca, L. R., T. Ogawa, et al. "Germ Cell Genotype Controls Cell Cycle During Spermatogenesis in the Rat." Biology of Reproduction 59, no. 6 (1998): 1371–7.


Male-biased Mutation Rates

See the Lecture Summary

Miyata, T., H. Hayashida, et al. "Male-driven Molecular Evolution: A Model and Nucleotide Sequence Analysis." Cold Spring Harbor Symposia on Quantitative Biology 52 (1987): 863–7.

Venn, O., I. Turner, et al. "Strong Male Bias Drives Germline Mutation in Chimpanzees." Science 344, no. 6189 (2014): 1272–5.


Germ Line Selection

See the Lecture Summary

Malter, H., J. Iber, et al. "Characterization of the Full Fragile X Syndrome Mutation in Fetal Gametes." Nature Genetics 15, no. 2 (1997): 165–9.

Goriely, A., G. McVean, et al. "Gain-of-function Amino Acid Substitutions Drive Positive Selection of FGFR2 Mutations in Human Spermatogonia." Proceedings of the National Academy of Sciences United States of America 102, no. 17 (2005): 6051–6.


Meiotic Recombination

See the Lecture Summary

Pecina, A., K. N. Smith, et al. "Targeted Stimulation of Meiotic Recombination." Cell 111, no. 2 (2002): 173–84.

Grey, C., P. Barthes, et al. "Mouse PRDM9 DNA-binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination." PLoS Biology 9, no. 10 (2011): e1001176.


Field Trip to the Whitehead Institute

See the Lecture Summary

No Assigned Readings

Chromosome Segregation

See the Lecture Summary

Lattao, R., S. Bonaccorsi, et al. "Giant Mitotic Spindles in Males from Drosophila Species with Giant Sperm Tails." Journal of Cell Science 125, no. 3 (2012): 584–8.

Close, R., J. Bell, et al. "Spermatogenesis and Synaptonemal Complexes of Hybrid Petrogale (Marsupialia)." Journal of Heredity 87, no. 2 (1996): 96–107.


Review Midterms

See the Lecture Summary

No Assigned Readings

Transcription and Chromatin State During Spermatogenesis

See the Lecture Summary

Levine, M., C. Jones, et al. "Novel Genes Derived from Noncoding DNA in Drosophila Melanogaster are Frequently X-linked and Exhibit Testisbiased Expression." Proceedings of the National Academy of Sciences United States of America 103, no. 26 (2006): 9935–9.

Soumillon, M., A. Necsulea, et al. "Cellular Source and Mechanisms of High Transcriptome Complexity in the Mammalian Testis." Cell Reports 3, no. 6 (2013): 2179–90.


Adaptive Evolution of Sperm Proteins

See the Lecture Summary

Wyckoff, G. J., W. Wang, et al. "Rapid Evolution of Male Reproductive Genes in the Descent of Man." Nature 403, no. 6767 (2000): 304–9.

Torgerson, D. G., R. J. Kulathinal, et al. "Mammalian Sperm Proteins are Rapidly Evolving: Evidence of Positive Selection in Functionally Diverse Genes." Molecular Biology and Evolution 19, no. 11 (2002): 1973–80.


Sperm Cooperation

See the Lecture Summary

Moore, H., K. Dvorakova, et al. "Exceptional Sperm Cooperation in the Wood Mouse." Nature 418, no. 6894 (2002): 174–7.

Fisher, H., and H. Hoekstra. "Competition Drives Cooperation Among Closely Related Sperm of Deer Mice." Nature 463, no. 7282 (2010): 801–3.


Sperm Competition

See the Lecture Summary

Moore, H., M. Martin, et al. "No Evidence for Killer Sperm or other Selective Interactions Between Human Spermatozoa in Ejaculates of Different Males in Vitro." Proceedings of the Royal Society Biological Sciences 266, no. 1436 (1999): 2343–50.

Pitnick, S., G. Miller, et al. "Males' Evolutionary Responses to Experimental Removal of Sexual Selection." Proceedings of the Royal Society Biological Sciences 268, no. 1471 (2001): 1071–80.


Student Presentations

See the Lecture Summary

No Assigned Readings